Investigators who studied a population of patients with metastatic clear cell renal cell carcinoma (mRCC) found that black men under age 50 had lower overall survival than other age groups, black women and white patients, according to a presentation at the ASCO Genitourinary Cancer Colloquium 2022.
“Most of the literature to date has focused on disparities affecting black patients with localized RCC,” said lead researcher Claud M. Grigg Jr., MD, of the Levine Cancer Institute in Charlotte, North Carolina. North. “But we understand very little about what factors impact outcomes in the metastatic setting. Oncologists and urologists should be aware that young black men have poor outcomes with this disease, but should still provide the same care as any other patient.
Dr. Grigg and colleagues’ study included 900 black men, 461 black women, 13,422 white men and 6,363 white women. In multivariate analysis, being black was significantly associated with a 14% increased risk of death compared to the overall cohort, the investigators reported.
When stratified by age and race, investigators observed that males had similar or better survival than females in most subgroups. Black men under age 50, however, had significantly lower median overall survival than black women, white women, and white men in the same age group (10.4 versus 17.1, 23.2, and 22.1 months, respectively).
“Potential hypotheses to explain this disparity include differences in obesity and incidence of smoking in this population as well as unmeasured factors impacting access to care,” the authors concluded in their study summary. .
Dr. Grigg’s team noted that black patients were less likely to have private insurance, lung metastases, or live in high-income ZIP codes. They were also more likely to have liver metastases.
Disclosure: Some study authors have declared affiliations with biotechnology, pharmaceutical and/or device companies. Please see the original citation for a full list of author disclosures.
Grigg C, Trufan SJJ, Riggs SB, et al. Survival of young black men with metastatic clear cell renal cell carcinoma. Featured at ASCO GU 2022; February 17-19, 2022. Abstract 294.